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British Medical Bulletin Advance Access published online on April 17, 2008
British Medical Bulletin, doi:10.1093/bmb/ldn016
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Clinical applications of musculoskeletal tissue engineering

Scott J. Roberts{dagger},{ddagger}, Daniel Howard{dagger}, Lee D. Buttery{dagger} and Kevin M. Shakesheff*,{dagger}

{dagger} Wolfson Centre for Stem Cells, Tissue Engineering and Modelling
{ddagger} Division of Medicinal Chemistry and Structural Biology, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, UK

* Correspondence to: Prof. Kevin Shakesheff, STEM CBS School of Pharmacy, University of Nottingham NG7 2RD, UK. E-mail: kevin.shakesheff{at}nottingham.ac.uk

Background: Current surgical techniques for the repair of the musculoskeletal system can be often limited by the availability, quality and quantity of materials, such as grafts to effect repair. This has led to the exploration and development of novel methods of intervention based on tissue engineering and regenerative medicine.

Source of data: This review summarizes the successes and investigations which are happening to date in the field of musculoskeletal tissue engineering. This is based on an extensive literature search and through basic research being performed by the authors.

Areas of agreement: Due to the constraints surrounding certain surgical techniques and restrictions on their use, novel procedures are required for the repair and regeneration of damaged tissues.

Areas of controversy: The choice of cell type has caused much debate within the tissue-engineering field. However it is widely accepted that currently only autologous primary/adult stem cells are fit for transplantation, until such times that optimized differentiation and selection protocols exist for embryonic stem cells.

Growing points: The current results of the clinical cases utilizing tissue engineered constructs for bone and cartilage repair provide insights for improvement of these techniques thus allowing treatments to become increasingly viable.

Areas timely for developing research: There is a need to better understand the integration of scaffolds and cell populations into the target tissue. This should provide vital information influencing scaffold manufacturing procedures and cell selection.

Keywords: Tissue engineering • regenerative medicine • musculoskeletal • embryonic stem cells • mesenchymal stem cells • scaffolds

Accepted for publication March 27, 2008.


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