British Medical Bulletin 51:332-345 (1995)
© 1995 The British Council
research-article |
The role of T-Iymphocytes in rheumatoid arthritis
Department of Rheumatology, The Medical School, Brimingham University Brimingham, UK
Abstract
The role of T lymphocytes in the pathology of rheumatoid arthritis (RA) is controversial. To some extent this has resulted from contradictory data, but even where specific points of fact are not in dispute, their interpretation often is.1–4 Nevertheless, the basic idea of a pathological T cell response in RA receives significant support from the work of several groups who have removed them by thoracic duct drainage, lymphapheresis or total lymphoid irradiation (TLI). Each of these procedures ameliorates RA; in the case of TLI which induces a profound and sustained decrease in CD4+ cells, the effect on synovitis was prolonged5.These observations are in line with the general assumption that the strong association of RA with HLA-DR molecules containing a particular conserved region of amino acids implies an important role for T cells in RA6, since the physiological role of HLA-DR molecules is to present antigens to T cells. In addition the association with Dw4 and related alleles is strongest for the most severe and persistent forms of disease7, arguing that T cells may be important not just in initiation of RA but also in its perpetuation. However, the infiltrating T cells seem to be remarkably inactive and as a population to lack specificity for any particular antigen, leading some to conclude that their role is either passive or irrelevant, while others contend that it is precisely this inactivity which is responsible for the persistence of RA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C H Burgoyne, S L Field, A K Brown, E M Hensor, A English, S L Bingham, R Verburg, U Fearon, C A Lawson, P J Hamlin, et al. Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse Ann Rheum Dis, June 1, 2008; 67(6): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Damsker, M. I. Bukrinsky, and S. L. Constant Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A J. Leukoc. Biol., September 1, 2007; 82(3): 613 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R J Verburg, R Flierman, J K Sont, F Ponchel, L van Dreunen, E W Levarht, M M Welling, R E M Toes, J D Isaacs, and J M van Laar Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration Ann Rheum Dis, October 1, 2005; 64(10): 1397 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ponchel, A. W. Morgan, S. J. Bingham, M. Quinn, M. Buch, R. J. Verburg, J. Henwood, S. H. Douglas, A. Masurel, P. Conaghan, et al. Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis Blood, December 15, 2002; 100(13): 4550 - 4556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chabaud, G. Page, and P. Miossec Enhancing Effect of IL-1, IL-17, and TNF-{alpha} on Macrophage Inflammatory Protein-3{alpha} Production in Rheumatoid Arthritis: Regulation by Soluble Receptors and Th2 Cytokines J. Immunol., November 15, 2001; 167(10): 6015 - 6020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Buckley, N. Amft, P. F. Bradfield, D. Pilling, E. Ross, F. Arenzana-Seisdedos, A. Amara, S. J. Curnow, J. M. Lord, D. Scheel-Toellner, et al. Persistent Induction of the Chemokine Receptor CXCR4 by TGF-{beta}1 on Synovial T Cells Contributes to Their Accumulation Within the Rheumatoid Synovium J. Immunol., September 15, 2000; 165(6): 3423 - 3429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Yocum, S. Allard, S. B. Cohen, P. Emery, R. M. Flipo, J. Goobar, S. Jayawardena, C. Job-Deslandre, R. W. Jubb, K. Kruger, et al. Microemulsion formulation of cyclosporin (Sandimmun Neoral(R)) vs Sandimmun(R): comparative safety, tolerability and efficacy in severe active rheumatoid arthritis Rheumatology, February 1, 2000; 39(2): 156 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aarvak, M. Chabaud, P. Miossec, and J. B. Natvig IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells J. Immunol., February 1, 1999; 162(3): 1246 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Beacock-Sharp, J. L Young, and J S H. Gaston Analysis of T cell subsets present in the peripheral blood and synovial fluid of reactive arthritis patients Ann Rheum Dis, February 1, 1998; 57(2): 100 - 106. [Abstract] [Full Text]
|
|