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British Medical Bulletin 51:437-448 (1995)
© 1995 The British Council

research-article

Immunology of systemic rheumatoid disease

N Snowden1 and R A Kay2

1Department of Immunology, Hope Hospital Salford, UK
2Immunology Research Group, University of Manchester Medical School Manchester, UK

Abstract

Extra-articular or systemic features occur commonly in seropositive erosive rheumatoid arthritis (RA). Clinical, pathological and immunogenetic evidence suggests that nodule formation, vasculitis and Felty's syndrome can be considered as manifestations of the same fundamental disease process as rheumatoid synovitis. However, while synovitis seems likely to be driven by macrophage activation induced by Th1 cells, systemic involvement in RA is characterised by B cell overactivity, immune complex formation and complement consumption, suggesting that Th2 cells are involved in the pathogenesis of extra-articular rheumatoid disease.


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