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British Medical Bulletin 51:368-384 (1995)
© 1995 The British Council

research-article

Cytokine expression in chronic inflammatory disease

F M Brennan, R N Maini and M Feldmann

The Mathilda & Terence Kennedy Institute of Rheumatology Hammersmith, London, UK

Abstract

In chronic inflammatory diseases, typified by rheumatoid arthritis, we speculated that upregulation and/or disregulation of cytokine production in inflamed tissue might contribute both directly and/or indirectly to the pathology in the synovial joint tissue. This chapter summarises studies performed principally by our own group over the last 9 years or so, but also by others in the field who have investigated the expression of cytokines in RA. From our studies we identified one particular cytokine, tumour necrosis factor {alpha} (TNF{alpha}) as an important, ‘pivotal’, molecule in the disease process. This concept has led to the initiation and completion of the first successful clinical trials in RA patients to verify this hypothesis, using a neutralising antibody to TNF{alpha}.


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